Meyer-Almes - LOEWE - SoftControl

LOEWE-Schwerpunkt "SoftControl" (2011-2014)

LOEWE-Schwerpunkt "Softcontrol" (2011-2014)

Prof. Dr. Meyer-Almes headed the sub-project  "Analysis of conformational changes of grafted polymers and protein interactions with switchable polymer films using fluorescence spectroscopy". Azobenzene was used to photocontrol the enzyme activity of histone deacetylase like amidohydrolase from Bordetelle/Alcaligenes. Further information can be found on the SoftControl-homepage and a poster.

Publications

M. Korbus, S. Backé, F.-J. Meyer-Almes, The cis-state of an azobenzene photoswitch is stabilized through specific interactions with a protein surface, J. Mol. Recognit. (2015)  DOI: 10.1002/jmr.2415

B. Horstmann, M. Korbus, T. Friedmann, C. Wolff, C.M. Thiele, F.-J. Meyer-Almes, Synthesis of azobenzenealkylmaleimide probes to photocontrol the enzyme activity of a bacterial histone deacetylase-like amidohydrolase, Bioorg Chem. 57, 155-61 (2014).

M. Korbus, G. Balasubramanian, F. Müller-Plathe, H. Kolmar, F.-J. Meyer-Almes, Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase, Biol Chem. 395, 401-12 (2014).